The north east will be represented by Labour and the UK Independence Party (UKIP) in the European Parliament for the next five years.
Labour polled 221,988 and took two seats for Jude Kirton-Darling and Paul Brannen, with UKIP polling 177,660 votes to gain a seat for Jonathan Arnott.
The Conservatives came third with 107,733 votes, while the Lib Dems received 36,093 and the Greens secured 31,605.
Berwick MP Sir Alan Beith said: “As we saw last time round, Euro elections are different and we will be working hard for my constituents ahead of next year’s elections.”
Julie Porksen, who will be fighting to retain the Berwick seat when Sir Alan retires in 2015, added: “Liberal Democrats have been here before in European elections and have shown that with our hard work and listening to local people on local issues we have gone on to win seats at Westminster.
“This was clearly a strong showing for UKIP and none of the parties with experience of government will be happy to see so many voters showing their dissatisfaction with mainstream politics. All of us will be working hard to regain their trust.”
Mr Arnott, the north east’s first UKIP MEP, said voters rejected “European union and uncontrolled immigration” and he intended to create ‘shock waves’ when he takes his seat in Brussels.
“Nigel Farage promised a political earthquake. We have caused that tonight,” said Mr Arnott. “It is time now to go to Brussels and to work together with any moderate, like-minded politicians and let us take the north east’s message to Brussels and let us create shockwaves there too.”
Labour doubled its representation in the region and rejoiced at ousting Martin Callanan, chairman of the European Conservatives and Reformists group.
Scott Dickinson, Labour’s prospective parliamentary candidate for Berwick, said: It’s a great result for Labour in Northumberland as our voters were instrumental in delivering the second seat for the party.
“It shows that we’re credible challengers to the Conservatives in Berwick and in Hexham and it’s a hugely disappointing result for the Conservatives in the county and a disastrous result for the Liberal Democrats who finished fourth in the poll.
I’ll be working hard with Jude and Paul to make sure Northumberland’s voice is heard loud and clear in Brussels and it’s vital that we make sure that the farming and tourism industry in the county get a fair deal.”
Ms Kirton-Darling said Labour was putting forward policies which are resonating on the doorstep - the living wage, addressing the health system, education.
Her new colleague Paul Brannen, who contested the Berwick seat in the 1997 General Election, added that Labour would listen to the concerns of those who “felt unable to vote for them in this election”.
Overall, only a third of people eligible to vote in the European elections in the region turned out at the polls. Seats in the European Parliament are allocated by a type of proportional representation.